- Nanoparticle locates to pituitary gland and inactivates gonadotrophs
- Ovary and testes become inactive
- Safe, non-surgical strategy for permanently disabling reproductive system
Abstract
UGA researchers have developed an intravenously injected nanoparticle, which localizes to the pituitary and binds to GnRH receptors that are located on gonadotrophs, which typically secret luteinizing hormone and follicle stimulating hormone. The nanoparticle acts on the ribosomes in the cell, inactivating them. The gonadotrophs then die in roughly two weeks time. There is no further secretion of luteinizing or follicle stimulating hormone. The ovary and testes then become inactive, and females cease estrous cycles. This permanently prevents breeding.
Advantages
This is a safe, non-surgical reproduction intervention for mammals.
Potential Applications
Spay/Neuter; Veterinary