2011-006 – “End-only” Functionalized Oligo Phenylene Ethynylenes: Synthesis, Photophysical and Biocidal Activity

Abstract

Background
Bacteria contamination can cause a variety of superficial and life-threatening skin/wound/internal infections. Over time, bacteria have become increasingly resistant to existing antibiotics. In efforts to address this dual threat, antibacterial research has turned to photophysical processes that utilize the absorption of visible and ultraviolet light to induce phototoxic reactions leading to bacterial damage and death. There is a present market demand for the development of photosensitizers with high efficiency, broad-spectrum, and controllable release antimicrobials. “End-only” functionalized oligophenylene ethynylenes (OPEs) have recently been found to be broad-spectrum and effective antibacterial agents because of their unique structure and optical properties. Synthesized oligomers show exceptional dark and UV-light activated biocidal activity against gram negative and gram positive bacteria and bacterial spores.

Technology Description
Researchers at the University of New Mexico and University of Florida have developed a method for synthesizing end-only functionalized oligo phenylene ethynylenes (OPEs), in addition to a method for incorporating them into various materials. Such compounds are characterized by exceptional dark and UV-light activated biocidal activity against gram negative and gram positive bacteria and bacterial spores. The described compounds can be utilized to form a reusable biocidal material or film, which not only inactivates, kills, or destroys trapped species but may also be employed as an active sensor monitored by steady state fluorescence or laser interferometry.

Advantages

  • High efficiency at inhibiting growth and killing of Gram-positive spores and Gram-negative bacteria under 365 nm radiation
  • Provides broad spectrum light-induced biocidal activity resulting in significant bacterial kills under low concentration of OPE
  • Offers controllable release
  • Straightforward synthesis requires only five steps

Potential Applications

  • Antiviral
  • Antibacterial
  • Antifungal
  • Biosensing
  • Biocides
  • Disinfectant

Contact Information

Name: Gregg Banninger

Email: GBanninger@innovations.unm.edu

Phone: 505-272-7908