(14MB075N) YAP1/OCT4: Small Molecule Inhibitors of the Protein-protein Interaction of YAP1 and OCT4 to Treat Cancer

Disruption of the OCT4-YAP1 interaction suppresses Sox2 expression as well as certain metabolic genes, preventing the self-renewal of stem-like cells thus preventing tumor initiation, progression, drug resistance and metastasis. Highly potent and selec…

Disruption of the OCT4-YAP1 interaction suppresses Sox2 expression as well as certain metabolic genes, preventing the self-renewal of stem-like cells thus preventing tumor initiation, progression, drug resistance and metastasis. Highly potent and selective disruptors of the Oct4-YAP1 interaction were identified by researchers here at Moffitt. These compounds can be developed into anti-cancer therapies for lung cancer and possibly other malignancies.

VIDEO: Disruption of the OCT4-YAP1 interaction as a therapy for lung cancer (Tech ID: 14MB075)

Website:

https://moffitt.org/research-science/academic-and-industry-partnerships/office-of-innovation/available-technologies/pharmaceuticals-biologics/14mb075n-yap1oct4-small-molecule-inhibitors-of-the-protein-protein-interaction-of-yap1-and-oct4-to-treat-cancer/