Compounds for disrupting microtubule networks and mitosis in brain cancer

 Project ID: D2014-42     Background   Primary brain tumors and secondary intracranial tumors from metastatic spread of other cancers (e.g., melanoma, lung carcinoma) have been inaccessible to therapy with microtubule-targeted…

 Project ID: D2014-42

Background

Primary brain tumors and secondary intracranial tumors from metastatic spread of other cancers (e.g., melanoma, lung carcinoma) have been inaccessible to therapy with microtubule-targeted agents (vincristine, vinblastine, paclitaxel) because the latter do not readily cross the blood-brain barrier.

Invention Description

Researchers from the University of Toledo have developed novel microtubule-targeted compounds that can effectively cross the blood-brain barrier. Lab studies have shown the compounds inhibit the Progression of Subcutaneous and Intracerebral Glioma Xenografts in Mice.

Applications

  • Brain metastases

Advantages

  • Can cross the blood brain barrier

IP Status:                          Issued US Patents: 9,023,871 and 9,061,994

Publications:       1.            Maltese W, et al. 6-MOMIPP, a novel brain-penetrant anti-mitotic indolyl-chalcone, inhibits glioblastoma growth and viability. Cancer Chemother Pharmacol. 2019 Feb;83(2):237-254.  

                               2.           Trabbic C J, et al., Synthesis and Biological Evaluation of Isomeric Methoxy Substitutions on Anti-Cancer Indolyl-Pyridinyl-Propenones: Effects on Potency and Mode of Activity. Eur J Med Chem. 2016 October 21; 122: 79–91.

                                3.           Trabbic C, et al., Synthesis and biological evaluation of indolyl-pyridinyl-properties having either mitosis or microtubule disruption activity. J Med Chem. 2015 Mar 12;58(5):2489-512.

                                4.           Robinson M W, et al., Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of non-apoptotic cell death. J Med Chem.2012 March 8; 55(5): 1940–1956.

Website:

http://utoledo.technologypublisher.com/technology/45874

Contact Information:

TTO Home Page: http://utoledo.technologypublisher.com

Name: Katherine Pollard

Title: Licensing Associate

Department: Technology Transfer

Email: katherine.pollard@utoledo.edu

Phone: 419-530-6228