- Protein-based biologics
- Drug discovery screening
A new method for isolating and identifying biomolecules that bind to a specific target epitope. This novel technology combines cell-free display, engineered protein scaffold libraries, and disulfide tethering methods into one optimized protocol that selectively enriches for polypeptides that are target-site specific. This technology can be used to identify polypeptide therapeutics for treating a broad range of diseases including cancer, where it is critical to ensure therapeutics target cancerous mutations without affecting normal proteins.
Phase of Development
The research is at a conceptual stage with some supporting in vitro data. Proof of concept demonstrating the technique can be used to perform a bulk enrichment of the peptide library against a test protein has been obtained.
This technology is now available for:
- Sponsored research
- Please contact our office to share your business’ needs and learn more.
Casim Sarkar, Ph.D. Associate Professor, Department of Biomedical Engineering
In vitro selection method for the engineering of protein-based high-affinity binders to targets of interest with a potential pharmacological value
Name: Rayla Vilar