A High Dynamic-Range Sensing Front-End For Neural Signal Recording Systems

Researchers led by Professor Dejan Markovic have developed an innovative front-end technology that enables implantable neuromodulation systems to record and stimulate simultaneously. This neural recording chopper amplifier can tolerate 80 mVpp DM and 6…

Researchers led by Professor Dejan Markovic have developed an innovative front-end technology that enables implantable neuromodulation systems to record and stimulate simultaneously. This neural recording chopper amplifier can tolerate 80 mVpp DM and 650 mVpp CM artifacts in a signal band of 1 Hz – 5 kHz, with a dynamic range of 74 dB in the spiked band and 81 dB in the LFP band. This implantable system overcomes the limitations of wall-plugged systems, such as limited duration of recordings (hours vs. weeks), risk of infection (does not require an open wound), and patient discomfort. Moreover, this system will enable neuroscientists to probe and investigate the brain in ways that current technologies do not support.

Abstract

UCLA researchers in the Department of Electrical Engineering have invented a novel neural recording chopper amplifier for neuromodulation systems that can simultaneously record and stimulate.

Website

https://techtransfer.universityofcalifornia.edu/NCD/28914.html?utm_source=AUTMGTP&utm_medium=webpage&utm_term=ncdid_28914&utm_campaign=TechWebsites

Advantages

  • Tolerates 650 mVpp CM and 80 mVpp DM artifacts 
  • Fabricated in 40 nm CMOS technology
  • Significantly improves Zin (5.3x) and the linear input range (2x)
  • Increases the maximum resistance of duty-cycled resistors (32x)
  • Does not require off-chip caps
  • Achieves comparable power and noise performance

Potential Applications

  • Closed-loop neuromodulation
  • Neural stimulation therapy for drug-resistant neurological conditions
  • Diagnosis/treatment of neurological disorders, such as epileptic seizures
  • Neuroprosthetic technologies to aid paralyzed patients
  • Brain-machine interfaces
  • Neurological investigative tool

Contact Information

Name: UCLA Technology Development Group

Email: ncd@tdg.ucla.edu

Phone: 310.794.0558