9587 – Grape Stilbenes for Improved Gut Function and Health

A method to improve poultry gut health by administering grape stilbenesGrape stilbenes improved mineral adsorption and decreased inflammatory responsePotential additive to poultry feed generated from a waste stream
  • A method to improve poultry gut health by administering grape stilbenes
  • Grape stilbenes improved mineral adsorption and decreased inflammatory response
  • Potential additive to poultry feed generated from a waste stream

Abstract

Invention Summary

Two beneficial polyphenolic compounds found in wine byproducts decrease intestinal inflammation, improve gut microbiome balance, and increase mineral bioavailability in an amniotic chick model system.

Technology Overview

Grapes have long been suspected of providing health benefits, including improved gastrointestinal function and a lower risk of cardiovascular disease. Due to their abundant derivative uses such as juice, wine, and raisins, grapes represent the United States’ highest production fruit crop by weight. Despite this large market, relatively little research has been done to understand the mechanisms by which these health benefits are achieved.

Previous supplements consisting of compounds extracted from grapes have been sold without a rigorous evaluation of in vivo physiological effects. The polyphenolic grape stilbene compounds described here (resveratrol and pterostilbene) demonstrate a marked effect of improved absorption of iron (85%) and zinc (44%) into the serum. Additionally, significantly lower (p < 0.05) expression of cytokine-encoding genes indicated decreased inflammatory response. Cornell researchers have, for the first time, directly demonstrated these health benefits in an animal model.

Website

https://cornell.flintbox.com/technologies/C29B991782E0490BACB1ED0AEE629A8F

Advantages

  • Improves absorption of nutrients already present in diet
  • Produced from a current waste product

Potential Applications

  • Prebiotic supplement to promote healthy gut microbiome
  • Food and beverage additive to achieve above health benefits

Contact Information

Name: Aris Despo

Email: add74@cornell.edu

Phone: 607-254-4698