Two mouse models have a knockout of receptors critical for resolving inflammation. These models are whole animal knockouts of either ERV1/ChemR23 or ALX/FPR2. Both receptors are G-protein coupled receptors that transmit signals related to the resolution of inflammation.
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Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner. FASEB J. 2020;34(8):10640-10656.
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