21-0104 Universal Platform for C-H Functionalization and Diversification of Small Molecules, Polymers, and Postconsumer Waste

No directing groups or reactive intermediates required Eliminates polymer chain scission to preserve thermomechanical properties Substrate serves as limiting reagent
  • No directing groups or reactive intermediates required
  • Eliminates polymer chain scission to preserve thermomechanical properties
  • Substrate serves as limiting reagent

Abstract:

The present invention is a platform for the introduction of a diverse range of functionality into aliphatic C-H bonds enabled by an easily prepared, shelf-stable reagent without the need for an exogenous initiator. This platform demonstrates a wide scope of accessible transformations and available substrates and unlocks challenging and previously undeveloped C-H transformations such as iodination and methylation. This method can be applied to the diversification of complex, late-stage small molecules for medical chemistry pursuits such as lead generation and SAR studies. In addition to its applicability to small molecules, this method is also demonstrated to convert commodity polymers and waste products such as polyolefins and plastic into higher value materials such as ionomers derived from post-consumer waste streams.

Website:

https://unc.flintbox.com/technologies/66784BE8D7164C80859EA7BC8078007A